@jayjoseph22 @DrEricKuelker @jersey_flight @bobkolker @Ryan_ETyler @DrAnnieHickox Schizophrenia Working Group of the Psychiatric Genomics Consortium. Biological insights from 108 schizophrenia-associated genetic loci. Nature 511, 421–427 (2014). https://t.
RT @Dong14Dong: 1. Biological insights from 108 schizophrenia-associated genetic loci This is multi-stage #Schizophrenia genome-wide associ…
RT @Dong14Dong: 1. Biological insights from 108 schizophrenia-associated genetic loci This is multi-stage #Schizophrenia genome-wide associ…
1. Biological insights from 108 schizophrenia-associated genetic loci This is multi-stage #Schizophrenia genome-wide association study in which the authors have identified 128 independent association spanning 108 conservatively defined loci. #CUinTheLab ht
・保存される108遺伝子座に統合失調症の原因となる変異がありそう ・原因遺伝子は脳や免疫系で発現する割合が高い 環境要因もあるようですが https://t.co/JJt0l5Wa4B
The catalyst that surprised us all: https://t.co/oi9xzgcTxO
@giorgiogilestro schizophrenia GWAS https://t.co/VStvirdFOy ---> complement component 4 (C4) pruning mechanisms https://t.co/8muPxiLnSU
@RCarhartHarris Thanks! Moving on, I go with Ripke et al https://t.co/AW641VH822 (GWAS studies dilute the commitment to SCZ). Gene variation has implications for psychedelic sampling and your (interesting) PMS. I go with Disruption from DID in DSM-5 or (co
RT @ThunderBearFire: Genes responsible for and Genetic heritability of Schizophrenia https://t.co/kvhHhlldBm https://t.co/E39D2C1ahl http…
Genes responsible for and Genetic heritability of Schizophrenia https://t.co/kvhHhlldBm https://t.co/E39D2C1ahl https://t.co/ERHX8oMBOq
@themichjam @AcademicChatter "Still just theories"? Are you kidding me?! https://t.co/qOV3evRY2z
Esquizofrenia y sistema inmunitario. Genética https://t.co/CJihZQpwmW
A plot of citations of the NIH funded papers so far shows that PGC's schizophrenia paper is the top most one as of today (3877 citations), an example of what can be achieved through teamwork. 2/ https://t.co/gyAfyhaHHK
.@dalygene #GRD20: Daunting realization that to find the polygenic signal underlying SCZ, etc would require tens of thousands of cases. But this helped pull the community together -- PGC SCZ GWAS found 108 loci with 37k cases https://t.co/PdIUmsALg5
@MrSam144 @sav_oise @ShorAlgorithm @Nachibi3 @ElRacer_ @Skyrandar @tontoncolonie @epenser @dirtybiology @HygieneMentale Enfin, cette étude parue dans nature sur les gènes associés à la schizophrénie (que l'on sait hautement héritable) devrait vous faire re
Usan marcadores específicos de F20 y F17! Me sorprende que el OR sea tan bajo a pesar de que manipularon toda la muestra. Y luego leo el artículo en el que se basa para los loci y ¡Valgame Dios! ... https://t.co/6vdGEPkptG https://t.co/c5wfH547x6 Hace falt
RT @Eric_Fauman: @SbotGwa Good overlap with loci associated with depression. Another interesting candidate for causality testing (@ksuhre).…
@SbotGwa Good overlap with loci associated with depression. Another interesting candidate for causality testing (@ksuhre). Does seeing a psychiatrist make one depressed? https://t.co/WBdg3oq1mw
Interesting seeing that strong signal at the beginning of Chr6 which is typical of many auto-immune diseases. This is consistent with the first large schizophrenia GWAS, where the strongest signal was also in this region: https://t.co/blrPDqF9ln
First of the last session at #BoG19: Guy Sella on should 'important genes' stand out in GWAS? Starts with Ripke et al, Nature, 2014 https://t.co/kqlbgGk0Ef schizophrenia GWAS image Asks: bulk of genes important for heritability? Or.... (missed the 2nd)?
RT @PGCgenetics: The PGC Schizophrenia group has been instrumental in the combining of study samples to allow very large GWAS to be carried…
RT @PGCgenetics: The PGC Schizophrenia group has been instrumental in the combining of study samples to allow very large GWAS to be carried…
The PGC Schizophrenia group has been instrumental in the combining of study samples to allow very large GWAS to be carried out. The aim is to expand these samples to include more than 100,000 individuals with schizophrenia. https://t.co/0rgmFriPGI https://
Another "non-nearest gene" is GRIA1 but here's the regional association plot from the original paper: https://t.co/ZQ7pJKXQba where the strongest p-value is at rs2973155 and GRIA1 is the closest gene https://t.co/xLWslTT36K https://t.co/OCRktNqhKV
RT @ksamocha: Anney (@ricanney): The Psychiatric Genomics Consortium (@PGCgenetics) got together as the consortium of consortia and was abl…
Anney (@ricanney): The Psychiatric Genomics Consortium (@PGCgenetics) got together as the consortium of consortia and was able to start finding significant loci for neuropsych conditions. Poster child was the 108 loci found for SCZ (https://t.co/sMpXMmvxSC
🌍Showing the power of international collaboration, the most recent analysis from this study identified even more risk genes: https://t.co/bTjKxIchgW #LoveTrinityResearch #LoveIrishResearch #HighlyCited2018
@agteien @MereteNesset Här till exempel. Se också referenslista; råttor t.ex. som man studerat ”schizofreni”/”schizofrenigener” på är ”antipsykotika”-behandlade råttor, och inte ”schizofrena” råttor... För någon sådan ”diagnos” finns inte bland djur./A htt
@hpashler @timothycbates I expect 96% of targets to fail in CNS (much less psychiatry), so I count myself a skeptic too :) That said, (post-hoc/alternate history) one could imagine DRD2 loci in Scz GWAS motivating antipsychotic drug design. https://t.co/C2
@Dr_R_Kurzrock GWAS studies like this one have implicated B cells in disease etilogy, but mechanisms ill-defined as far as I know. https://t.co/02WoPtlqMm https://t.co/Oio1Ggdptg
@and_kell @awesomelyautis1 @JulieandBrookie They've found quite a few genes linked to autism, and they find more all the time. Why do you claim that an environmental trigger is always required? See e.g. https://t.co/CK8ahzhXeb https://t.co/iWk04UO6oF htt
RT @RudolfUher: Top ten papers in psychiatry 2000-2018 #4 The genetic revolution in psychiatry, spearheaded by @PGCGenetics with first harv…
RT @RudolfUher: Top ten papers in psychiatry 2000-2018 #4 The genetic revolution in psychiatry, spearheaded by @PGCGenetics with first harv…
RT @RudolfUher: Top ten papers in psychiatry 2000-2018 #4 The genetic revolution in psychiatry, spearheaded by @PGCGenetics with first harv…
RT @RudolfUher: Top ten papers in psychiatry 2000-2018 #4 The genetic revolution in psychiatry, spearheaded by @PGCGenetics with first harv…
RT @RudolfUher: Top ten papers in psychiatry 2000-2018 #4 The genetic revolution in psychiatry, spearheaded by @PGCGenetics with first harv…
Top ten papers in psychiatry 2000-2018 #4 The genetic revolution in psychiatry, spearheaded by @PGCGenetics with first harvest of causal variants for #schizophrenia Now the single largest repository of evidence on causation of mental illness. @s_mccarroll
RT @PGCgenetics: .@psychgenomics introduces the meeting and the value and achievements of @PGCgenetics, esp. the SCZ (https://t.co/pjtjXb2J…
.@psychgenomics introduces the meeting and the value and achievements of @PGCgenetics, esp. the SCZ (https://t.co/pjtjXb2JqN) and MDD (https://t.co/7CXL2v0Lp8) work
This is actually #amazing😮 https://t.co/98HyxR7Veo #Genetics #Schizophrenia #article #nature #study
Biological Insights From 108 Schizophrenia-Associated Genetic Loci https://t.co/An85wTg0H0
@WiringTheBrain @ErikIngelsson @GENES_PK Even for schizophrenia, I suspect an additive model (polygenic score from latest common variant screen https://t.co/MyUSyXuDvO) will play quite impt role. Others like @bmneale may have more to add here.
@AllenFrancesMD At the same time, genome wide studies using ”simple” DSM diagnostic categories have been very fruitful in the past 5 years, e.g. https://t.co/u5JAxRDDxg
Three loci on X-chromosome associated with #SCZ in 2014. https://t.co/66CEjZpeqC https://t.co/2jha4V83yZ https://t.co/zp8AoDRHmY
@sydsvenskan @ttnyhetsbyran 5/n rs16977195 har inte dykt upp i större GWAS-studier rörande schizofreni. t.ex. https://t.co/Av72WjWDcS
...and they're still jet-lagged. https://t.co/Iv3flSslDN
Open Access UCL Research: Biological insights from 108 schizophrenia-associated genetic loci https://t.co/lGIh0IvF8K
Open Access UCL Research: Biological insights from 108 schizophrenia-associated genetic loci https://t.co/lGIh0IvF8K
RT @PGCgenetics: Schizophrenia GWAS paper https://t.co/E6G2TQwMUI was one of NIH's 15 most cited in 2014! https://t.co/NqZEZ3YmCX
Schizophrenia GWAS paper https://t.co/E6G2TQwMUI was one of NIH's 15 most cited in 2014! https://t.co/NqZEZ3YmCX
Dr Feuk mentions the work of Michael O'Donovan on identifying #schizophrenia associated loci at #NGSNordic https://t.co/gLRZXEs3ii
@PerKohler fast kandidatgensspåret är stendött sen flera år. GWAS (och sekvenering) går, tänker jag, bättre än sådär https://t.co/H8HJbwRIUT
@devirotica https://t.co/OETnOhifoi loci em 2014, pelo menos, para esquizofrenia. Provavelmente mais desde então.
Naomi Wray on finding sweet spot in samples need for disease genetics, recall SZ https://t.co/hPDq8TaZsC -> https://t.co/BEAxwAIwCc #ICQG5
Biological insights from 108 schizophrenia-associated genetic loci : Nature : Nature Publishing Group https://t.co/RTi8g6tASN
RT @rplenge: Note to self: genetics of schizophrenia identifies targets of approved drugs (D2 receptor blockade). https://t.co/C54ud0xsU5
RT @rplenge: Note to self: genetics of schizophrenia identifies targets of approved drugs (D2 receptor blockade). https://t.co/C54ud0xsU5
RT @rplenge: Note to self: genetics of schizophrenia identifies targets of approved drugs (D2 receptor blockade). https://t.co/C54ud0xsU5
RT @rplenge: Note to self: genetics of schizophrenia identifies targets of approved drugs (D2 receptor blockade). https://t.co/C54ud0xsU5
RT @rplenge: Note to self: genetics of schizophrenia identifies targets of approved drugs (D2 receptor blockade). https://t.co/C54ud0xsU5
We have such a long way to go in understanding illnesses like schizophrenia, but research like this really helps https://t.co/aHYRBvoSPw
RT @rplenge: Note to self: genetics of schizophrenia identifies targets of approved drugs (D2 receptor blockade). https://t.co/C54ud0xsU5
RT @rplenge: Note to self: genetics of schizophrenia identifies targets of approved drugs (D2 receptor blockade). https://t.co/C54ud0xsU5
RT @rplenge: Note to self: genetics of schizophrenia identifies targets of approved drugs (D2 receptor blockade). https://t.co/C54ud0xsU5
Note to self: genetics of schizophrenia identifies targets of approved drugs (D2 receptor blockade). https://t.co/C54ud0xsU5
There are 108 genetic loci associated with Schizophrenia https://t.co/RtueqmntXO https://t.co/TqhvuuCVrm
RT @J9_Austin: Well deserved paper of the year award for this: http://t.co/OB1hNPgSnT congrats @stephanripke & my PhD supervisor Mick O'don…
RT @J9_Austin: Well deserved paper of the year award for this: http://t.co/OB1hNPgSnT congrats @stephanripke & my PhD supervisor Mick O'don…
RT @J9_Austin: Well deserved paper of the year award for this: http://t.co/OB1hNPgSnT congrats @stephanripke & my PhD supervisor Mick O'don…
RT @AFPopgen: The ISPG award session starts with the Elliott Gershon paper of the year award to... The PGC2-SCZ paper! http://t.co/SHdjkwcd…
RT @J9_Austin: Well deserved paper of the year award for this: http://t.co/OB1hNPgSnT congrats @stephanripke & my PhD supervisor Mick O'don…
RT @AFPopgen: The ISPG award session starts with the Elliott Gershon paper of the year award to... The PGC2-SCZ paper! http://t.co/SHdjkwcd…
RT @J9_Austin: Well deserved paper of the year award for this: http://t.co/OB1hNPgSnT congrats @stephanripke & my PhD supervisor Mick O'don…
RT @AFPopgen: The ISPG award session starts with the Elliott Gershon paper of the year award to... The PGC2-SCZ paper! http://t.co/SHdjkwcd…
RT @AFPopgen: The ISPG award session starts with the Elliott Gershon paper of the year award to... The PGC2-SCZ paper! http://t.co/SHdjkwcd…
Well deserved paper of the year award for this: http://t.co/OB1hNPgSnT congrats @stephanripke & my PhD supervisor Mick O'donovan #wcpg2015
RT @AFPopgen: The ISPG award session starts with the Elliott Gershon paper of the year award to... The PGC2-SCZ paper! http://t.co/SHdjkwcd…
RT @AFPopgen: The ISPG award session starts with the Elliott Gershon paper of the year award to... The PGC2-SCZ paper! http://t.co/SHdjkwcd…
The ISPG award session starts with the Elliott Gershon paper of the year award to... The PGC2-SCZ paper! http://t.co/SHdjkwcdUs #WCPG2015
@David_Dobbs My guess is that they have characterized some of the 108 hits http://t.co/mHM2ZSfoNc The top hit is interesting.
ESQUIZOFRENIA VINCULADA A MAIS DE 100 MARCADORES GENÉTICOS EM NOVO ESTUDO DE DNA Cientistas encontraram mais de... http://t.co/MR9JNTwpWA
Biological insights from 108 schizophrenia-associated genetic loci http://t.co/4lABOwoa9o via @NatureNews
PV, latest on schizophrenia genetics: Biological insights from 108 schizophrenia-associated genetic loci http://t.co/BEAxwAIwCc #GBDM
PV, latest on schizophrenia genetics: Biological insights from 108 schizophrenia-associated genetic loci http://t.co/BEAxwAIwCc #GBDM
PV, latest on schizophrenia genetics: Biological insights from 108 schizophrenia-associated genetic loci http://t.co/BEAxwAIwCc #GBDM
PV, latest on schizophrenia genetics: Biological insights from 108 schizophrenia-associated genetic loci http://t.co/BEAxwAIwCc #GBDM
3. Or highlight converging biological pathways that are relevant to disease etiology- such as calcium biology http://t.co/J6XgbTmJ0Q
Echoes related findings for schizophrenia http://t.co/sQ01KK2vkP Human genetics points to need for focus on immunity in neurological disease
@DrAhmadAlShayea اعتقد ان هذه المقاله تعتبر من افضل ما وصل له من الناحيه الجينيه في الطب النفسي تحياتي وتقديري http://t.co/jOe47OxTd0
Biological insights from 108 schizophrenia-associated genetic loci http://t.co/3D8KdCtHHJ
No single gene for schizophrenia. Instead a hundred are robustly associated across populations and cultures. http://t.co/fZH9wWlwK7
No single gene for schizophrenia. Instead a hundred are robustly associated across populations and cultures. http://t.co/fZH9wWlwK7
No single gene for schizophrenia. Instead a hundred are robustly associated across populations and cultures. http://t.co/fZH9wWlwK7
.@dgmacarthur fair? autism: small-effect size commn vars: http://t.co/dM0c68aTKC; scizph: small effect size rare var: http://t.co/pN9XtbNBIw
.@dgmacarthur fair? autism: small-effect size commn vars: http://t.co/dM0c68aTKC; scizph: small effect size rare var: http://t.co/pN9XtbNBIw
Biological insights from 108 schizophrenia-associated genetic loci : Nature : Nature Publishing Group http://t.co/5UgxAMsxRb
108 loci for schizophrenia (nature) http://t.co/cgixTIxVMs
Featured publication: Biological insights from 108 schizophrenia-associated genetic loci http://t.co/MrTMPIrW6g